oa Wound Healing Southern Africa - Deconstructing the chronic wound : review
Chronic wounds have traditionally been defined as those that fail to progress through an orderly and timely sequence of repair, such that healing does not take place in a predictable time frame. More objective definitions of chronic wounds are 'those that have failed to heal within three months'; 'a wound that has not decreased by 30% of its size within four weeks'; 'if a wound is not 30% smaller by week four, it will not heal by week twelve'; and so on. The crux of the matter is that these wounds reach an impasse in their healing progression which is not easily explained and has remained a mystery for decades. On 'deconstructing' the chronic wound phenomenon in recent years, two factors appear to play an increasingly important role in the evolution of chronicity - exaggerated inflammation and allied to that, infection, particularly involving biofilm.
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