oa Wound Healing Southern Africa - Hypergranulation tissue : evolution, control and potential elimination : original research
|Article Title||Hypergranulation tissue : evolution, control and potential elimination : original research|
|© Publisher:||Medpharm Publications|
|Journal||Wound Healing Southern Africa|
|Author||A.D. Widgerow and K. Leak|
|Publication Date||Jan 2010|
|Pages||1 - 3|
|Keyword(s)||Doncaster and Bassetlaw Foundation Trust Hospital, Hypergranulation, Pilonidal sinus, University of the Witwatersrand and Wound dressing regimen|
Granulation tissue typically consists of an abundance of blood vessels mixed with fibrous connective tissue. Granulation tissue grows from the base of a wound and is able to fill the wound, facilitating eventual epithelialisation and wound closure. Continued wound healing will only take place once internal inter- and intracellular signalling notify keratinocytes and epithelial cells that the tissue is ready for their cellular migration. Prolonged stimulation of fibroplasia and angiogenesis results in hypergranulation, a potential problem for the wound healing process.
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