oa Wound Healing Southern Africa - The role of advanced glycation end products in the hyperinflammatory response of diabetic wounds : general review
|Article Title||The role of advanced glycation end products in the hyperinflammatory response of diabetic wounds : general review|
|© Publisher:||Medpharm Publications|
|Journal||Wound Healing Southern Africa|
|Author||A. Gould, C. Naidoo, D. Kruger and G. Candy|
|Publication Date||Jan 2011|
|Pages||25 - 28|
|Keyword(s)||Advanced glycation end products, Diabetic wounds, Hyperinflammatory response and University of the Witwatersrand|
Chronic wounds are a frequent complication in diabetic patients and contribute significantly to morbidity and mortality. In the hyperglycaemic state, advanced glycation end products (AGEs) form, affecting collagen cross-linking, cytokine, nitric oxide and growth factor production and molecular signalling pathways. AGE receptors are upregulated and as it activates NF-kappaB, a host of inflammatory cytokines are expressed, exacerbating the self-sustaining inflammatory response seen in diabetic wounds. Therapeutic strategies include inhibiting the formation of AGEs, either directly or by inhibiting the formation of intermediates, and blocking the AGE receptor. A more complete understanding of the biology of the diabetic wound healing process is imperative in the development of successful treatment of diabetic wounds.
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