oa Wound Healing Southern Africa - The hypermetabolic response to burn injury and modulation of this response : an overview : general review

Volume 8, Issue 2
  • ISSN : 1998-8885
  • E-ISSN: 2076-8893



Burn injuries are followed by a profound hypermetabolic response, which is characterised by circulatory, physiological, catabolic and immune system changes. This response can persist for up to 24 months post burn. It is mediated by a 50-fold elevation in plasma catecholamines, cortisol and inflammatory cells. This leads to whole body catabolism, significantly elevated resting energy expenditure (REE) and multi-organ dysfunction. These patients have a number of metabolic derangements, including increased REE, increased cardiac work, increased myocardial oxygen consumption, marked tachycardia, severe lipolysis, liver dysfunction, severe muscle catabolism, increased protein degradation, insulin resistance and growth retardation. Early excision and grafting is the cornerstone of management. No treatment modality supersedes early wound coverage. Early enteral nutrition, thermoregulation and resistance training are other components of care. Basic management should be correctly executed before pharmacological agents are employed.

Loading full text...

Full text loading...


Article metrics loading...


This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error