oa Central African Journal of Medicine - Possible immunity in man to Trypanosoma Rhodesiense estimation of antibody titre by fluorescent antibody test

Volume 16, Issue 4
  • ISSN : 0008-9176



It has been hypothesised by Blair, Burnett-Smith and Gelfand (1968) that people constantly exposed to tsetse flies acquire a relative immunity to T. rhodesiense, possibly because they are constantly inocculated with other trypanosomes which confer cross-immunity with T. rhodesiense. In order to test the validity of this hypothesis, fluorescent antibody estimations were done on 67 sera from people living in an area considered to be endemic for T. rhodesiense. Of these 67 sera 14 gave weakly positive results for antibodies. The antigen used was T. rhodesiense�in rat blood. No overt infections with T. rhodesiense were noted in blood slides from these people. It is considered that the finding of 14 weakly positive fluorescent antibody tests in these patients is compatible with the hypothesis.

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