oa Central African Journal of Medicine - Variation in amyloid incidence in Scotland and Rhodesia

Volume 20, Issue 11
  • ISSN : 0008-9176



The examination of Congo red or Sirius red stained material in polarized light gives a more accurate assessment of the incidence of amyloidosis than routine staining methods. In a general hospital in Scotland clinically significant disease occurred in 1,35 per cent. of a series of 221 cases coming to autopsy. Microdeposits of amyloid were found in 5,4 per cent. of this series, predominantly in superficial vessels of the brain. In a similar hospital for African patients in Rhodesia clinically significant disease was not found in a series of 183 autopsies. Micro-deposits were found in brain in 1,09 per cent. The pathological significance of the micro-deposits is doubtful. The Congo red and Sirius red methods are not specific for amyloid and some of the difficulties in interpretation are discussed.

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