oa Central African Journal of Medicine - An Extended Field Trial of Pyrimethamine Combined with Dapsone in the Prophylaxis of Malaria

Volume 21, Issue 9
  • ISSN : 0008-9176



A proprietary combination of pyrimethamine and dapsone, was used in the Sangwe Tribal Trust Land in the Rhodesian Lowveld, between October, 1973, and May, 1974, in an attempt to control the incidence of malaria. The season proved to be an exceptionally wet one and conditions for malaria transmissions were therefore unusually favourable. In spite of this, with good organisation it was possible to achieve a satisfactory level of control of transmission. After some initial resistance the local population readily accepted the drug. A satisfactory paediatric dosage regimen was established. Some degree of control was achieved by issuing Deltaprim fortnightly but a weekly issue appeared preferable. When the test combination was given fortnightly there appeared to be a higher incidence of gametocytaemia.

Loading full text...

Full text loading...


Article metrics loading...


This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error