oa Central African Journal of Medicine - Liver disease in typhoid fever

Volume 24, Issue 9-Supplement
  • ISSN : 0008-9176



The incidence of clinical and biochemical evidence of liver disease was investigated prospectively in patients with typhoid fever. Thirty-three percent of patients had significant hepatomegaly. Biochemical evidence of active liver disease was detected in 55 per cent., and two patients had hepatic granulomata on liver biopsy. All patients recovered completely and there was no evidence of residual liver damage. These findings were confirmed in a six-year retrospective study of 52 patients. The occurrence of hepatic involvement in typhoid fever is usually subclinical and resolves as the patient recovers from the primary disease.

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