oa Central African Journal of Medicine - Adverse drug reactions in a developing country: problems encountered in a surveillance programme in a Nigerian hospital

Volume 26, Issue 11
  • ISSN : 0008-9176



A six week period of intensive monitoring of adverse drug reactions revealed 40 serious cases. The sex distribution was 45% female, 55% male and they varied in age from 8 months to 63 years with 50% of them within the 20-40 years range. Skin lesions, gastrointestinal symptoms, central nervous and neuromuscular symptoms were predominant. The greatest number of reported side effects was seen with the antimalarial compounds and antimicrobial agents. An unusual case of epidermolysis caused by sulfa triad and psychotic episodes following procaine penicillin were highlighted. A case of suramin toxicity, manifested by hyperpigmentation, generalized muscle weakness and hyperesthesias of the palms of the hand and soles of the feet was seen. A new antiemetic metoclopramide (Plasil) was found to cause dyskinesia in children.

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