oa Central African Journal of Medicine - Megaloblastic anaemia with normal mean cell volume

Volume 27, Issue 1
  • ISSN : 0008-9176



An elevated mean cell volume (M. C. V.) is generally considered to be a prerequisite for the diagnosis of megoblastic anaemia, although it is well established that this association does not necessarily apply if there is a concomitant iron deficiency or cytotoxic chemotherapy. However there have been recent reports indicating that this traditional concept is not invariable. Review of 11 cases of megaloblastic anaemia admitted to this hospital during 1978 established that four of these (36%) presented with a normal M. C. V. In no case was there associated iron deficiency or chemotherapy.

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