oa Central African Journal of Medicine - Drug resistance of plasmodium falciparum in Africa with particular reference to chloroquine resistance in Zimbabwe

Volume 30, Issue 2
  • ISSN : 0008-9176



Recent reports on drug resistant malaria in Africa are reviewed. Chloroquine sensitivity of Plasmodium falciparum from malaria infected patients resident in S.E. and N.E. Zimbabwe was determined in vivo and in vitro. There was no evidence of chloroquine resistance in 32 and 6 patients who underwent W.H.O. Standard 7 day and Extended 28 day tests consecutively. Mean parasite clearance time was 2.1 days with 25mg chloroquine base/kg body weight. Macro in vitro tests done on blood from six patients did not demonstrate chloroquine resistance. Schizont maturation was totally inhibited at a chloroquine concentration of 1.00n mols/ml of blood.

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