oa Central African Journal of Medicine - Single dose metrifonate in the treatment of urinary schistosomiasis in an area of low prevalence and intensity of infection

Volume 32, Issue 6
  • ISSN : 0008-9176



Urine specimens from 638 primary school children in Gokwe Communal Land were examined for S. haematobium ova, and the 187 (29%) children who were excreting eggs were treated with a single 10 mg/kg dose of metrifonate. Further urine samples were collected from all children, whether treated or not, 48 weeks later, and examined for ova. The overall cure rate was 50,8%, and in children not cured egg excretion was reduced by an average 59,9%. Only 12,1% of children were excreting > 50 eggs per ml of urine before treatment, and after this was reduced to 3,9%. Increased egg excretion following treatment was noted in 15 (8,0%) of the infected children, while 21 (4,7%) children with negative urines, and therefore not treated, were excreting eggs 48 weeks later. Thus even in an area where the prevalence and intensity of infection is low, single-dose metrifonate may play a cost-effective role in the control of urinary schistosomiasis

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