oa Central African Journal of Medicine - Serum collagen glucosyltransferase activity in experimentally-induced hepatocellular carcinoma in rats

Volume 32, Issue 9
  • ISSN : 0008-9176



The present study has been carried out mainly to examine the sequential changes of serum collagen glucosyltransferase activity levels with the evolution of experimental hepatocellular carcinoma, Rats were fed with 0,06 per cent of the azodye, 3-methyl-4- dimethylaminoazobenzene (3- MeDAB). A significant increase in the serum enzyme activity levels was observed in the experimental animal groups four weeks into the experiment which rose progressively over the duration of the study. The serum enzyme activity levels in the carcinogen-fed animal group increased five times the control mean enzyme activity levels at 0 week to 18 weeks and also about five times its mean enzyme activity level at 0 week, when hepatic cancer appeared in the liver. The data thus indicate that the serum collagen glucosyltransferase may be a useful assay in the diagnosis of primary hepatoma.

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