oa Central African Journal of Medicine - Stability of oral reconstituted penicillins

Volume 33, Issue 6
  • ISSN : 0008-9176



Thirteen commercially available oral reconstituted penicillin products were evaluated for active ingredient content over seven days after storage at 25°C and at 33°C with evaporative cooling. All but three of the products evaluated retained at least 90 per cent of their labelled potency over seven days at 25°C, and evaporative cooling of products stored at 33°C showed the same degradation as the preparations stored at 25°C. It is apparent, therefore, that evaporative cooling could prove to be a cheap and effective alternative to refrigeration, in maintaining stability of these products in areas of the country without cooling facilities, and thereby improve overall health care. Wherever possible, however, solid dosage forms of penicillins should be used because of the inherent instability of solutions.

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