oa Central African Journal of Medicine - Hyperuricaemia and foetal haemoglobin levels in homozygous sickle cell disease

Volume 33, Issue 8
  • ISSN : 0008-9176



Serum uric acid (SUA) levels in 53 adults with homozygous sickle cell disease. in the steady state, was determined. The values were compared with those seen in age and sex-matched normal adults. A statistically significant difference was seen in their mean values. No evidence of renal dysfunction was observed as indicated by the lack of elevation of blood urea levels. Eighteen (34%) of these patients had SUA levels of more than 6 mg/dl (0,35 mmol/l). Sickle cell disease patients with SUA level of more than 6 mg/dl (0,35 mmol/l) had significantly lower foetal haemoglobin levels when compared with those with uric acid level of 6 mg/dl or less (p < lt; 0,01). The implication of these findings are discussed.

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