oa Central African Journal of Medicine - Comparison of in vitro dissolution of proprietary Methyl Dopa preparations

Volume 34, Issue 1
  • ISSN : 0008-9176



On comparison of dissolution of Methyl Dopa tablets it was apparent that of the three brands investigated the sugar-coated product had the lower dissolution rate. The most likely reason for this difference would be the length of time taken for the tablet to disintegrate. The two film-coated preparations, trade marks of Aldomet and Hypotens, on the other hand had similar dissolution characteristics, despite differences in disintegration time and can be assumed to have similar effects in a clinical situation. This would, however, have to be verified using human volunteers.

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