oa Central African Journal of Medicine - Sero-conversion of infants to three doses of oral poliomyelitis vaccine

Volume 34, Issue 12
  • ISSN : 0008-9176



Blood from 59.3 months old infants attending Mbare Clinic was collected by heel-pricking. Only 25 ul of blood was collected by using calibrated micro-blotting paper, and was immediately put into vials containing 17 ul cold neutralization medium. These collections were done at intervals of 12, 16, 20 and 24 weeks of age. All samples collected were processed and examined in the laboratory by the Neutralization Test for antibodies to type 1, 2, 3 polioviruses. In this study a titre of â?¥ 1:16 was considered to be protective. Before vaccination, the antibody titre to all three types of poliovirus (1,2,3), was 3.39 percent, 5.0 percent, and 0.0 percent respectively. However, four weeks post OPV 1 the protective positivity rate was 59.52 percent, 64.29 percent and 64.29 percent for the three types (1,2,3) respectively. But after these infants had received OPV 2 and 3, the protective rate was 100 percent for all types, indicating the importance of giving all three OPV.

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