oa Central African Journal of Medicine - High dose tobramycin therapy and nephrotoxicity

Volume 34, Issue 3
  • ISSN : 0008-9176



Drug nephrotoxicity occurs more commonly in patients with pre-existing renal disease. A young man with unknown asymptomatic renal disease and acute gonococcal urethritis received high doses tobramycin therapy and developed acute on chronic renal failure. Because of the relatively high incidence of chronic renal disease, especially in the young Nigerian population, high dose aminoglycoside therapy should be used with the utmost caution and restraint.

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