oa Central African Journal of Medicine - Acute lymphoblastic leukaemia in a Nigerian adult with sickle cell anaemia

Volume 34, Issue 7
  • ISSN : 0008-9176



The first case of an adult with sickle cell anaemia developing acute lymphoblastic leukaemia (ALL) is reported. There appears to be no aetiological relationship between the two disorders. The patients suffered three relapses of his ALL which were closely associated with severe pain crises. It is probable that in this patient relapse of ALL was a precipitating factor for sickle cell crises. Regular red cell support will usually be necessary during induction and maintenance therapy in such patients. Where facilities are available and there is HLA compatible Hb AA or AS sibling donor, a bone marrow transplantation may offer the best hope in view of the poor survival of sickle cell anaemia patients with leukaemia so far reported. Autologous transplantation for those without suitable donors, undertaken in first remission, will obviate the need for maintenance therapy.

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