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oa Central African Journal of Medicine - Serum biochemical profile during scorpion venom (Leiurus Quinquestriatus L.) intoxication in weaning Charles Foster rats

Volume 34, Issue 8
  • ISSN : 0008-9176

 

Abstract

Serum effects of freeze dried scorpion venom (Leiurus quinquestriatus L.) on inbred Charles Foster rats were studied (in placebos and test groups n=10) by injecting (SC) venom at 2 and 4mg/kg dose levels. By cardiac puncture, blood was collected after 4 to 6 hours of intoxication and serum was analyzed for total proteins, bilirubin, cholesterol, albumin-globul in ratio (AGR), chlorides, urea,serum glutamic oxalic transminase (SGOT), serum glutamic pyruvic transminase (SGPl) SGPT/SGOT ratio, urea nitrogen ratio (UNR) , alkaline phosphatase (AP). Significant rise in SGOT, urea, UNR, AP,cholesterol at 4mg/kg dose and globulin, total and direct bilirubin, urea, cholesterol at 2mg/ kg dose were observed. A fall in AGR at 2mg/kg and at 4mg/kg of venom, marked decrease in SGPT. SGPT/SGOT ratio, albumin, globulin, AGR, bilirubin were noted. AT LD50 dose (3mg/kg), the animal died due to shock, myocarditis, and autonomic storm. Post-mortem also confirmed hepatic, cardiac nephrogenic, autonomic and central (autonomic nervous and central nervous systems) effects.

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/content/CAJM/34/8/AJA00089176_573
1988-08-01
2019-08-22

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