oa Central African Journal of Medicine - The effect of prolonged exposure of rats to sub-Iethal dose of acetaminophen

Volume 37, Issue 4
  • ISSN : 0008-9176



In this report. we studied the effect or sub-lethal doses and duration or acetaminophen given intraperitoneally (i.p) to male albino rats; on the level of pc methaemoglobin and some liver function tests: Alkaline phosphatase, free and conjugated bilirubin. The study showed that the increase in pc methaemoglobin, free and conjugated bilirubin in rats treated with acetaminophen are significantly (P<0.05) greater than those for the control rats and that the measured parameters increase with acetaminophen concentrations. The results also show that the free bilirubin is probably displaced from plasma albumin.

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