oa Central African Journal of Medicine - New trends in chloroquine efficacy in the treatment of malaria: Chloroquine-resistant Plasmodium falciparum in Anambra and Benne States of Nigeria

Volume 37, Issue 6
  • ISSN : 0008-9176



Increasing malaria treatment failures with chloroquine (C25) and reports of chloroquine resistant Plasmodium falciparum (CRPF) led to the field survey of two sites (Agbani and Jato-Aka) both in Primary Health Zone A, using WHO - in vivo seven-day test, modified to 14-day follow-up period. Of the 922 children studied, high transmission rates of 40 pc and 59,2 pc were found in Agbani and Jato-Aka respectively. Varying degrees of parasitologic failures (CRPF), 52 pc in Agbani and 60 pc in Jato-Aka were confirmed. However, chemotherapy with C25 significantly reduced the clinical symptoms of malaria infection, even in the CRPF - cases. The clinical success in the two study sites were 69 pc and 94 pc respectively.

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