oa Central African Journal of Medicine - Multicentre study of the treatment of primary liver cancer in Africa with two anthracycline drugs

Volume 38, Issue 11
  • ISSN : 0008-9176



Hepatocellular carcinoma (HCC) is among the twelve commonest cancers affecting mankind. In tropical Africa HCC is the most common malignant tumour, particularly among men. In Kyadondo County of Uganda the incidence rate is 5,1 cases per 100 000 men. In Nigeria the figure quoted for both sexes is 5,9 per 100 000 population. In Zimbabwe the incidence among the Black population is 20,8 per 100 000, while in Mozambique the figure is 103,8 per 100 000 males. These figures are in contradiction to what is observed in Europe and North America. In England HCC occurs in 2,5 per 100 000, while in North America it is seen in 1,8 per 100 000. The aim of this study was to assess the usefulness of Epirubicin in African HCC and compare its effectiveness with that of its parent compound Doxorubicin as well as determining the optimal doses for both compounds in the treatment of African HCC.

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