oa Central African Journal of Medicine - A skin irritant phorbol ester from Euphorbia cooperi N E Br

Volume 38, Issue 12
  • ISSN : 0008-9176



From the fresh latex of Euphorbia cooperi N E Br was isolated by partition and chromatographic methods, a diterpene ester 12-deoxyphorbol-16-isobutyrate-13-tigliate. The phorbol ester exhibited highly irritant activity on the mouse ear. Since skin irritancy is an indication of possible tumour promotion, the use of this plant as a medicine should be discouraged.

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