oa Central African Journal of Medicine - Comparison of four commercial enzyme-linked immunosorbent and one agglutination assays for the detection of HIV antibodies in sera from Zimbabwe

Volume 39, Issue 10
  • ISSN : 0008-9176



Sera from 871 AIDS and AIDS related complex patients were used to evaluate four ELISA and one agglutination assays. Commercial tests compared were Abbot, Wellcoyzyme, Biotest, Du Pont and Serodia. Wellcozyme and Serodia had the highest sensitivity (96,8 pc and 98,8 pc respectively) but the lowest specificity (53,3 pc and 46,5 pc respectively). Du Pont was the least sensitive test (89,1 pc). Biotest and Abbot were comparable - Biotest had a higher sensitivity (93,2 pc as compared with 90,6 pc) but Abbot had a higher specificity (94,1 pc as compared with 89, 1 pc). Thus, Abbott and Biotest both had a satisfactory high sensitivity and specificity and could thereby be recommended for use in screening of HIV-1 antibodies in south east Africa.

Loading full text...

Full text loading...


Article metrics loading...


This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error