oa Central African Journal of Medicine - Serum fatty acids profile of uncontrolled insulin dependent diabetic patients and the effect of improved metabolic control

Volume 39, Issue 12
  • ISSN : 0008-9176



We investigated fatty acid composition in 20 uncontrolled insulin dependent diabetic patients for a period of 12 weeks. Hyperglycaemic control indices were also carried out during the study. The plasma levels of 18:3 w 6; 20:3 w 6; 18:1 w 9 polyunsaturated and saturated fatty acids had changed to near normal levels.This study suggests that Î? 6 Î? 9 desaturates activity is influenced by insulin. The study also highlights a possible explanation for the accumulation of oleic acid in diabetes. This might have implications in dietary supplementation in diabetic patients.

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