oa Central African Journal of Medicine - Trisomy 18 - Edwards syndrome: a report of three patients

Volume 39, Issue 5
  • ISSN : 0008-9176



Communicable and non-communicable diseases present stimultaneously but not with equal frequency. In most developing countries communicable diseases receive greater attention, to the neglect of such non-communicable diseases as genetic disorders, particularly those affecting children. Accordingly, such diseases are less definitively diagnosed. Nevertheless, the burden of these disorders is heavy on both parents and clinicians. It has been estimated that genetic and congenital malformations have an incidence of six to seven pc. of which 0,5 pc. are due to chromosomal disorders. Apart from sickle cell disease, perhaps the most easily diagnosed genetic abnormalities are the chromosomal disorders. Their clinical index of suspicion is always high but confirmation is usually necessary. Information on prevalence of Edwards syndrome among black Africans is scanty or is not well-documented. In this paper, we report three cases of Edwards syndrome confirmed by chromosome analysis. Their features are compared with those cited in the literature.

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