1887

oa Central African Journal of Medicine - The clinical picture of Cushing's syndrome in childhood

Volume 5, Issue 11
  • ISSN : 0008-9176

 

Abstract

(1) In children under the age of ten, Cushing's syndrome is almost invariably due to adrenal carcinoma. After this age, adrenal hyperplasia becomes an important cause. (2) Carcinomas are biochemically pluripotent with the result that the syndrome is a mixed one, combining features of Cushing's and the adrenogenital syndrome. (3) Markedly raised urinary levels of 17-ketosteroids and dehydroepiandrosterone are suggestive of adrenal carcinoma. ( 4) Biochemical and hormonal studies may give conflicting results. The final diagnosis can only be made at operation.

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/content/CAJM/5/11/AJA00089176_5318
1959-11-01
2019-12-16

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