oa Central African Journal of Medicine - The clinical picture of Cushing's syndrome in childhood

Volume 5, Issue 11
  • ISSN : 0008-9176



(1) In children under the age of ten, Cushing's syndrome is almost invariably due to adrenal carcinoma. After this age, adrenal hyperplasia becomes an important cause. (2) Carcinomas are biochemically pluripotent with the result that the syndrome is a mixed one, combining features of Cushing's and the adrenogenital syndrome. (3) Markedly raised urinary levels of 17-ketosteroids and dehydroepiandrosterone are suggestive of adrenal carcinoma. ( 4) Biochemical and hormonal studies may give conflicting results. The final diagnosis can only be made at operation.

Loading full text...

Full text loading...


Article metrics loading...


This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error