oa Central African Journal of Medicine - Organophosphate poisoning

Volume 9, Issue 12
  • ISSN : 0008-9176



The organophosphate insecticides are an important cause of poisoning. Signs and symptoms result from the inhibition of cholinesterase with a resultant accumulation of acetylcholine. The chief threat to life is respiratory depression. Absorption is rapid and occurs from all surfaces. Treatment depends on the prevention of further absorption of poison, on atropinination, on the reactivation of cholinesterase and on the prevention and treatment of respiratory depression. The potential dangers of phenothiazine derivatives in this condition are stressed.

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