oa African Journal of Laboratory Medicine - Prolonged febrile illness due to CTX-M-15 extendedspectrum β-lactamase-producing infection in Nigeria : case studies

Volume 1, Issue 1
  • ISSN : 2225-2002
  • E-ISSN: 2225-2010



We report on an 8-year-old patient with septicaemia unresponsive to therapy for five weeks. Undetected, extended-spectrum β-lactamase (ESBL) production by the infecting strain was regarded as responsible for treatment failure. Intravenously administered imipenem during the sixth week led to sustained resolution of fever. Resource-limited hospitals can incur prohibitive costs from ESBL-producer infections because of diagnostic limitations and consequent treatment failure involving prolonged supportive therapy.

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