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n African Journal for Physical Health Education, Recreation and Dance - Determinants of association of hyperhomocysteinaemia and metabolic disorders : a review - : health

Volume 21 Number 1.2
  • ISSN : 1117-4315

Abstract

Hyperhomocysteinaemia may complicate diseases of metabolic origin. This would make standard therapy less effective with slow recovery progress, health deterioration and socioeconomic implications, if not detected and treated for, promptly. The study was aimed at establishing factors that determine and influence the association of hyperhomocysteinaemia with obesity, diabetes mellitus, hypertension and dyslipidaemia. The study was a cross-sectional literature review. Relevant articles and papers were analysed. Review articles were excluded, although original references from them were cited. Science Direct, Google Scholar, PubMed, NIH Public Access and PMC databases of literature search were used. All articles and papers that referred to homocysteine or hyperhomocysteinaemia and metabolic disorders or metabolic parameters were assessed. Hundred and thirty articles and papers were retrieved but only 87 of them were found relevant. After analysis of the articles and literature papers, personal viewpoints and comments were made. Insulin resistance, low nitrous oxide level, low level and functionally defective HDL, age, overt diabetic nephropathy and deficiency of vitamin B12 and folate were identified as determinants of the association of hyperhomocysteinaemia with obesity, diabetes mellitus, hypertension and dyslipidaemia.

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/content/ajpherd/21/Issue-12/EJC172401
2015-03-01
2020-10-24

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