n African Journal for Physical Health Education, Recreation and Dance - A systematic review on the effect of HIV infection on motor and cognitive development of infants and toddlers - : health

Volume 21 Number 1.2
  • ISSN : 1117-4315


The purpose of this systematic meta-analysis was to determine motor and cognitive developmental impairment in HIV infected children aged 0 to 42 months. A systematic search was done to identify relevant articles. Identified studies were assessed independently by two reviewers using a quality assessment tool. Data were entered into Review Manager Software and meta-analyses were performed. The I2 heterogeneity statistic test was used to determine the variability across studies and if present was the random effects model used for analysis. The initial search yielded 319 studies. After screening and thorough assessment of the identified studies, 11 were included in the systematic review with a total population of 1 444 participants. Research designs varied across studies. The meta-analysis produced a combined prevalence of motor delay was 83% (CI 74.98 to 90.57) and for cognitive delay was 76 % (CI 65.89 to 85.72). The prevalence of mild motor delay was 15.26% (95% CI: 11.19 to 19.33) and for mild cognitive delay was 21.85% (95% CI: 10.40 to 33.30). The prevalence of 64.53% (95%CI: 54.13 to 74.94) for significant motor delay and 51.94% (95% CI: 40.92 to 62.96) for significant cognitive delay. This systematic review aimed at developing our current understanding of the prevalence of motor and cognitive development in children infected with HIV. The findings suggest that there is a high prevalence of motor and cognitive developmental delay in children infected with HIV.

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