n African Journal for Physical Health Education, Recreation and Dance - Treatment outcomes of HIV infected children receiving antiretroviral therapy at the ALERT centre in Addis Ababa, Ethiopia : public health intervention for maternal and child health

Supplement 2
  • ISSN : 1117-4315


Antiretroviral therapy (ART) coverage for children in the sub Saharan region is slightly below the global figures; and globally children continued to have less access to ART than adults. This study aimed to determine the treatment outcome of children who have received ART treatment for at least 24 weeks, and enrolled to treatment over five years period between March 2005 and December 2010. A five-year retrospective records review was conducted using electronic medical records of paediatric patients who were enrolled in an ART programme in Addis Ababa, Ethiopia. ART initiation was 6.4 ± 4.1 inter-quartile range years of age, and 61.4% children were older than 5 years of age, while 56 (8.6%) were under 18 months at the time of initiation of ART showing significant delay in diagnosing HIV infected children. After six months there was significant clinical and immunologic response. The mean difference at baseline and six months for CD4 count was 251 (n= 374, CI: 219, 283, p < 0.000) and the mean difference for weight was 1.67kg (n= 301, CI: 1.15, 2.19, p < 0.000). The mean difference for CD4 count after 12 months compared with 6 months were -64.7 (n= 238, CI: -100.5 - 29, p < 0.000). Most children presented in advanced clinical and immunological suppression state but there were statistically significant improvements in weight, CD4 count, after six months of treatment with HAART which were the core parameters to measure success of ART.

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