n African Journal of Reproductive Health - Extracellular calcium and magnesium in preeclampsia and eclampsia : original research article

Volume 11, Issue 2
  • ISSN : 1118-4841
  • E-ISSN: 2141-3606


The cause of pre-eclampsia remains unknown and calcium and magnesium supplement are being suggested as means of prevention. The objective of this study was to assess magnesium and calcium in the plasma and cerebrospinal fluid of Nigerian women with pre-eclampsia and eclampsia.

Setting was University of Benin Teaching Hospital, in Nigeria. It was a cross-sectional study comprising of eleven patients and twenty-three controls. The mean, standard deviation and Standard Error of Mean (SEM) were calculated. Student 't' test method was applied.
Plasma calcium was significantly lower in patients than controls (9.2 ± 1.02 Vs 9.98 ± 0.87mg/dl, P 0.043) "t" test. The CSF calcium and magnesium levels were lower in patients than controls, (5.66 ± 1.22 vs 6.67 ± 1.15mg/dl, P 0.043 and 1.75 ± 0.56 vs 1.91 ± 0.19mg/dl, P 0. < 0.0001) respectively.
There is extracellular calcium and magnesium reduction in patients with pre-eclampsia and eclampsia. This reduction may have a cause and effect relationship with these disorders.

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