n Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie - Die ontwerp en sintese van 'n belowende reeks piroolkarbaldehiede as potensiële MIV-1 integrase-inhibeerders : referaatopsomming

Volume 30, Issue 1
  • ISSN : 0254-3486
  • E-ISSN: 2222-4173


Screening of an HIV-1 IN model against database-derived chemical structures identified pyrrole-carbaldehydes as targets for further development. Chemical synthesis using a facile one-pot reaction resulted in the generation of a compound library. Preliminary toxicity and efficacy assays of the water-soluble HCl-salt derivatives of each compound support the in silico predictions.

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