n Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie - 'n Vloeichemiestrategie vir die sintese van neurologiese farmaseutiese middels : referaatopsomming

Volume 35 Number 1
  • ISSN : 0254-3486
  • E-ISSN: 2222-4173



A flow-through strategy for the synthesis of clozapine under pressurised, superheated conditions using a Uniqsis Multi-X flow chemistry system which demonstrates improvements over the conventional batch route. Synthesis of clozapine characteristically involves a four-step synthesis. These key steps are applicable to many other syntheses and have already shown remarkable improvements over the traditional batch process routes.

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