n African Vision and Eye Health - Repeatability of central and peripheral corneal thickness measurements with the iVue100 optical coherence tomographer : original research

Volume 75 Number 1
  • ISSN : 2413-3183
  • E-ISSN: 2410-1516
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Accurate assessment of corneal thickness is essential in corneal refractive surgery, contact lens wear and corneal pathology.

To assess the repeatability (intra-observer, inter-observer and inter-session) of central (0 mm - 2 mm), mid-peripheral (2 mm - 5 mm) and peripheral (5 mm - 6 mm) corneal thickness measurements using the iVue 100 spectral domain optical coherence tomographer (SD-OCT).
Optometry Eye Clinic at the University of KwaZulu-Natal (UKZN).
Corneal thickness measurements were taken on 50 healthy participants by two observers independently. A second set of readings was taken by one observer on another session. Repeatability was assessed using Bland-Altman analysis, the intraclass correlation coefficient, coefficient of variation and one-way analysis of variance (ANOVA) analysis.
For all corneal regions, the intraclass correlation coefficients for observer one ranged from 0.942 to 0.999 and that for observer two ranged from 0.946 to 0.999, indicating good intra-observer repeatability. Using linear regression, the corneal thickness measurements were found to be comparable (within 1 µm of each other) in all regions with the exception of the nasal and temporal mid-periphery and periphery. The inter-session repeatability was based on the measurements of observer one only with the mean differences ranging from 0.02 µm to 0.63 µm. Linear regression revealed no significant differences between session 1 and session 2 ( > 0.05) except for the measurement of minimum corneal thickness.
This study found evidence of good intra-observer, inter-observer and intersession repeatability of central, mid-peripheral and peripheral corneal measurements with the iVue 100 SD-OCT.

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