oa Current Allergy & Clinical Immunology - Leukotriene receptor antagonists in patients with asthma and allergic rhinitis : review article

Volume 19, Issue 4
  • ISSN : 1609-3607



Many asthmatics also have allergic rhinitis. The important link between upper and lower airway disease seems to be through a common pathology which affects similar epithelial structures, and the inflammatory process is the common factor where upper and lower airway diseases coexist. Inadequately controlled allergic rhinitis in asthmatic patients can contribute towards increased asthma exacerbations and poorer symptom control, which may increase medical resource use. Prompt and effective treatment of nasal disease with an anti-inflammatory therapy can have a marked beneficial effect. Recently there has been renewed interest in the value of the leukotriene receptor antagonists in the systemic management of these two closely linked diseases. Among children with asthma and concomitant allergic rhinitis, initiating montelukast compared with initiating inhaled steroids (for asthma) in usual practice resulted in lower costs of asthma 'rescue and acute' medications and lower costs of (anti)allergy medications. Appropriate therapy of one or both conditions may alter the natural course of the overall inflammatory airway disease, and would almost certainly impact on patients' quality of life as well as the treatment costs.

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