oa Current Allergy & Clinical Immunology - Immunodeficiency diseases presenting in adults - diagnosis and management : review article

Volume 21 Number 1
  • ISSN : 1609-3607



In adults with recurrent regional infections, it is mandatory to exclude an underlying predisposing anatomical defect. Secondary causes of immune deficiency are the commonest cause in adults presenting with recurrent infections. Primary immune deficiency can present for the first time in adults; as in children, failure to consider this diagnosis remains a major cause of diagnostic delay. Common variable immune deficiency (CVID) is the commonest antibody deficiency seen in adults. An approach to diagnosis is suggested with relevant screening tests based on the clinical picture, to be followed by further advanced assays where required. A multidisciplinary team approach is advocated in the management of patients with immune deficiency. Rapid advances in immunology hold the promise of dissecting primary immune deficiency and also of uncovering immune defects in clinical situations where reasons for recurrent infections are currently unexplained.

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