oa Current Allergy & Clinical Immunology - Common variable immunodeficiency - focus on some active immunoprophylaxis issues : short report

Volume 21 Number 2
  • ISSN : 1609-3607



Common variable immunodeficiency (CVI) is a complex syndrome including heterogeneous clinical conditions involving patients suffering from various degrees of quantitative and qualitative hypogammaglobulinaemia, depending on a deficient synthesis and release of specific antibody classes, based on a very broad spectrum of genetic-mediated abnormalities. The pathogenetic pathways of the defective antibody production are numerous, and they have still not been completely elucidated. A different, usually reduced, but sometimes unpredictable, immune response to active immunisation procedures (vaccination schedules) may result.

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