oa Current Allergy & Clinical Immunology - Gastrointestinal syndromes in food allergy : review article

Volume 21 Number 2
  • ISSN : 1609-3607



Gastrointestinal (GI) clinical syndromes can be categorised by immunopathophysiology into disorders with an acute onset after ingestion, mediated by food-specific IgE antibody (e.g. oral allergy syndrome (OAS)), those that are chronic in nature and sometimes associated with IgE (e.g. eosinophilic gastroenteropathies) and those that are T-cell-mediated (e.g. food protein-induced disorders). OAS is usually associated with allergic rhinoconjunctivitis and allergy to pollen, especially to birch, grass, ragweed and mugwort. Symptoms of OAS are confined to the oral cavity. The diagnosis of this disorder is primarily clinical. can occur at any age and should be considered in the differential diagnosis of patients presenting with chronic GI symptoms such as abdominal pain, nausea, vomiting, diarrhoea, failure to thrive and GI bleeding. GI mucosal biopsies are mandatory for the definitive diagnosis of these disorders. Food allergy may play a causative role in some patients and must be sought for. Treatment options include dietary elimination, elemental diet, corticosteroid therapy (oral or topical) and anti IL-5. present well-characterised immunological responses (T-cell-mediated reactions) to dietary protein, cow's milk and soya protein in particular. They present in infancy or early childhood and usually resolve by age 1-3 years. Dietary elimination and elemental feeds (extensively hydrolysed (eHF) or amino-acid formula) are the only treatment available for these disorders.

Loading full text...

Full text loading...


Article metrics loading...


This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error