oa Current Allergy & Clinical Immunology - Fixed drug eruption : skin focus

Volume 21 Number 3
  • ISSN : 1609-3607



Skin reactions secondary to the intake of drugs may occur as a result of specific immune allergy directed at the drug or its metabolite or by non-immune mechanisms. The latter are more common and may result from mechanisms such as non-immune mast cell or basophil degranulation or idiosyncratic reactions. Drug reactions may also be referred to as predictable (type A) or non-predictable (type B). The presenting skin lesions may vary from purpura, urticaria, eczematous, morbiliform (measles-like), erythema multiforme, fixed drug reaction, Steven Johnson's syndrome (SJS) to toxic epidermal necrolysis (TEN).

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