oa Current Allergy & Clinical Immunology - H antihistamines in allergic disease : review article

Volume 22, Issue 2
  • ISSN : 1609-3607



Histamine (one of the key mediators released from mast cells and basophils), plays a major role in the pathophysiology of allergic diseases, including rhinitis, urticaria, asthma and anaphylaxis. Histamine exerts its effects through its interaction with one of four distinct receptors (H, H, H, H). In allergic disease, it is the H antihistamines which are of primary benefit, although H antihistamines may also play a therapeutic role.

H antihistamines remain first-line medications for the treatment of allergic rhinoconjunctivitis and urticaria. Second-generation antihistamines are preferred to their predecessors because of better benefit-to-risk ratios. The newer antihistamines are not only more potent, but also have anti-allergic and anti-inflammatory properties. Although they are more expensive than the traditional antihistamines, the cost is substantially offset by their superior efficacy and safety profile when used in recommended dosages.

Loading full text...

Full text loading...


Article metrics loading...


This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error