oa Current Allergy & Clinical Immunology - Hypersensitivity to local anaesthetics - 6 facts and 7 myths : review article

Volume 22, Issue 3
  • ISSN : 1609-3607



Local anaesthetics (LAs) are commonly used drugs. In spite of their widespread use, true hypersensitivity appears to be very infrequent. In fact most of the adverse reactions are due to pharmacological, toxic or vasovagal effects of LAs.

Our review of the literature has shown that true allergy to LA is in fact exceptional. Skin tests for LA allergy, including skin-prick tests (SPT) and intradermal (ID) tests, have poor sensitivity and specificity. True LA allergy, when appropriate, has to be confirmed by challenge. Provocation challenge is safe and well tolerated.

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