oa Current Allergy & Clinical Immunology - Eosinophilic oesophagitis

Volume 23, Issue 1
  • ISSN : 1609-3607



Eosinophilic oesophagitis (EO) is a mixed IgE-mediated and non-IgE (cell)-mediated food allergy. Adults present predominantly with dysphagia and food impaction. Children present predominantly with vomiting, gastro-oesophageal reflux that does not respond to medical treatment, food refusal and failure to thrive. The hallmark of the condition is oesophageal biopsy showing >15 eosinophils per high power field and exclusion of other similar disorders especially gastro-oesophageal reflux disease (GORD). Skinprick and patch testing are useful to identify food allergens responsible for triggering EO. Dietary manipulation has the best long-term results but almost equivalent results can be achieved with topical steroid administration or systemic steroids. There is urgent need for study of EO in South Africa, assessing the prevalence in high-risk groups, the role of food allergies and the success of alternative methods of treatment.

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