oa Current Allergy & Clinical Immunology - The preschool asthmatic - at an interface of marches - implications for diagnosis and treatment : short report

Volume 23, Issue 1
  • ISSN : 1609-3607



The concept of the allergic or atopic march is well known to paediatricians and allergists. This phenomenon is one of a progression of allergic or atopic disease expression from food allergy in early infancy, through atopic eczema, then to allergic rhinitis in early childhood and finally to asthma, the final expression. By age 5 or 6 years most atopic infants will have outgrown eczema but will be on a path to significant airway disease, the final insult born of genetic, epigenetic and environmental interactions in early life. The patho-physiology of this state appears to be driven by TH2 cytokines operating in excess, while TH1 pathways, as well as many innate immune structures, are somehow down-regulated.

Loading full text...

Full text loading...


Article metrics loading...


This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error