oa Current Allergy & Clinical Immunology - A case of microscopic polyangiitis - : case report

Volume 23, Issue 3
  • ISSN : 1609-3607



The association of rapidly progressive glomerulonephritis (GN) and pulmonary haemorrhage has been described in : (i) immune complex GN, mainly systemic lupus erythematosus; (ii) antiglomerular basement membrane GN; and (iii) antineutrophil cytoplasmic autoantibody (ANCA) with renal and pulmonary disease. ANCAs constitute markers of a group of systemic vasculitis including Wegener's granulomatosis, microscopic polyangiitis (MPA), Churg-Stauss angiitis and necrotising and crescenteric GN without extrarenal involvement. Two patterns of ANCA have been described by indirect immunofluorescence : a cytoplasmic pattern (c-ANCA) to proteinase 3 and perinuclear pattern (p-ANCA) with myeloperioxidase antibodies (MPO).

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