oa Current Allergy & Clinical Immunology - Henoch-schönlein purpura - a review : review article

Volume 23, Issue 3
  • ISSN : 1609-3607



Henoch-Schönlein purpura (HSP), the commonest childhood vasculitis, is typified by skin, joint, gastrointestinal tract and renal involvement. It shows peak incidence between the ages of 4 and 6 years and has a recurrence rate of 30%. Investigations are useful in differentiating HSP from other vasculitides but the diagnosis is clinical. Renal damage via an immune complex glomerulonephritis is the most serious long-term complication and warrants the greatest attention from clinicians : to establish who requires long-term follow-up, renal biopsy and immunosuppressive therapy. Immunosuppressive regimens are varied, and local experience with corticosteroids and azathioprine, as well as reported studies, is discussed in more detail.

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