oa Current Allergy & Clinical Immunology - Juvenile dermatomyositis : review article

Volume 23, Issue 3
  • ISSN : 1609-3607



Juvenile dermatomyositis (JDM) is a rare autoimmune vasculopathy of childhood. The presenting features are protean but primary features are skin rash and muscle weakness, accompanied by laboratory evidence of inflammation and antibodies to cellular components. Magnetic resonance imaging (MRI) has been shown to be sensitive in the diagnosis, and new diagnostic criteria are being established. Recent advances in immunogenetics have begun to identify genetic and autoimmune profiles and the underlying immune mechanisms responsible for the inflammation causing muscle damage. This understanding has helped the development of treatment protocols for early and aggressive therapy which offers hope of improved outcomes and less morbidity.

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