oa Current Allergy & Clinical Immunology - Gastro-oesophageal reflux and asthma in children - comorbidity or coincidence? : review article

Volume 25, Issue 2
  • ISSN : 1609-3607



Gastro-oesophageal reflux (GOR) is commonly associated with asthma and is cited as an aggravating factor for poorly controlled asthma in adults and children. Children with GOR may present with respiratory symptoms such as cough rather than with heartburn. Studies estimate the prevalence of GOR in asthmatic children to be between 19.3% and 80%. Acid suppression does not usually improve asthma control, a result borne out by a study of lansoprazole in which lung function, quality of life and poor asthma control did not improve. Adverse events, notably respiratory infections and activity-related bone fractures, were more common in the proton pump inhibitor (PPI) treated group. Severe asthmatics with poor control or with symptoms of GOR may warrant a trial of PPI therapy, but this therapy should be used with caution.

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